出版:考虑在选择高脂肪、高果糖和高胆固醇饮食诱导实验非酒精性脂肪肝病实验动物模型

文摘

非酒精性脂肪肝病(NAFLD)是复杂与代谢性疾病(包括肥胖,葡萄糖耐受不良和胰岛素抵抗)和包含一系列的障碍包括脂肪变性、非酒精性脂肪肝(NASH)和纤维化。啮齿动物摄入高脂肪(高频;∼40千卡%脂肪包括脂肪含有更高浓度的饱和脂肪酸和反式脂肪酸),高果糖(HFr)和高胆固醇饮食(HC)显示许多纳什的临床相关的特点,以及其他代谢紊乱。C57BL / 6小鼠最常用的动物模型,因为它们可以开发重要的代谢紊乱包括与纤维化严重纳什经过数月的喂养,但其他模型也敏感。大量的饮食(即包含这些不同的因素。,HF, HFr, and HC), either alone or in combination, makes the choice of diet difficult. This methodology review describes the efficacy of these nutrient manipulations on the NAFLD phenotype in mice, rats, guinea pigs, hamsters, and nonhuman primates. Nonalcoholic fatty liver disease (NAFLD) is intricately linked to metabolic disease (including obesity, glucose intolerance, and insulin resistance) and encompasses a spectrum of disorders including steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis. Rodents consuming high-fat (HF; ∼40 kcal% fat including fats containing higher concentrations of saturated and trans fats), high-fructose (HFr), and high-cholesterol (HC) diets display many clinically relevant characteristics of NASH, along with other metabolic disorders. C57BL/6 mice are the most commonly used animal model because they can develop significant metabolic disorders including severe NASH with fibrosis after months of feeding, but other models also are susceptible. The significant number of diets that contain these different factors (i.e., HF, HFr, and HC), either alone or in combination, makes the choice of diet difficult. This methodology review describes the efficacy of these nutrient manipulations on the NAFLD phenotype in mice, rats, guinea pigs, hamsters, and nonhuman primates.

参考:

bloom Radhakrishnan,史蒂文·F Yeung嘉裕客,Maisa米安图内斯,迈克尔Pellizzon,考虑在选择高脂肪、高果糖和高胆固醇饮食诱导实验非酒精性脂肪肝病实验动物模型、当前发展营养5卷,12个问题,2021年12月,nzab138, https://doi.org/10.1093/cdn/nzab138